Clinical inquiries. What are the best treatments for herpes labialis?

There are 3: valacyclovir, acyclovir, and topical penciclovir. valacyclovir, 2 g twice in 1 day taken during the prodromal stage of herpes labialis, reduces the episode duration and time to healing. Acyclovir, 400 mg, taken 5 times a day for 5 days, decreases the pain duration and healing time to loss of crust (strength of recommendation [sor]: a, based on randomized controlled trials [rCTs]). Topical penciclovir 1%, acyclovir 5%, or docosanol 10% also decrease the duration of pain and healing time (sor: a, based on rCTs). The best prophylaxis for herpes labialis is oral valacyclovir 500 mg daily; it reduces the frequency and severity of attacks (sor: B, based on rCT). sunscreen may be effective in sunlight-induced recurrence (sor: B, based on 2 small crossover rCTs).